Cycle 22: ML-guided MOF discovery and fresh sponsor prospect

Retrospective

Cycle 21 ran clean end-to-end: the Fe₂VAl thermoelectric Heusler analysis post is live in #thermoelectrics with 25 route executions and a clear comparison to the Ru₂TiSi cycle, the Parzer email draft is shared for approval, and the Renaissance Philanthropy sponsor email draft is also posted. The compact four-item pipeline pattern (paper → analysis → email → sponsor) continues to work well. The main improvement this cycle: MOFs are a structurally different beast from anything we've tested so far (open frameworks, large unit cells, organic linkers), so the analysis should surface genuinely new information about how Ouro's ML models handle these systems, not just repeat the validation loop.

What This Plan Covers

This plan runs cycle 22 end-to-end in the MOF domain and drafts a fresh sponsor outreach email. It does not touch pending items on other quests: the Walsh email approval (019f47d5, waiting until July 12), the Zakaryan email approval (019f48e8, waiting until July 12), the July 13-14 follow-up wave (019f480c, waiting until July 13), the Parzer email approval (this quest, just closed), the blocked audit update and catalysis prospect items (019f4ddc), or the GGen polymorph post (019f4ddc).

Cycle 22: ML-guided MOF discovery. This is the first outreach cycle targeting the #mofs team. MOFs are a natural test bed for Ouro's ML models because they invert most assumptions from dense intermetallic screening: open frameworks with large unit cells (>100 atoms), organic linkers that introduce chemical complexity beyond what ALIGNN and Orb v3 were trained on, and property targets (surface area, pore volume, gas adsorption) that go beyond formation energy and band gap. The cycle follows the established pipeline: deep-read a recent paper with specific MOF structures, generate CIFs, run Orb v3 relaxation with P1 collapse check, run MP hull energy and ALIGNN formation energy routes, and publish an analysis post in #mofs. The key question: do models that collapse on Laves phases and preserve symmetry on Heuslers behave yet differently on open-framework structures?

Sponsor outreach email draft. Both previously identified sponsors (Sloan Foundation, Renaissance Philanthropy) have been drafted on prior quests. This plan identifies a new sponsor prospect aligned with materials ML, open science, or clean energy — likely Gordon and Betty Moore Foundation (Science program, supports data-intensive discovery), Wellcome Leap (ambitious quantitative science programs), or Breakthrough Energy (climate technology). Draft a personalized email translating a specific community open question into a fundable opportunity.

Negative Constraints

No duplication of pending items on quests 019f47d5, 019f48e8, 019f480c, or 019f4ddc.

No materials science research work (screening chains, bias correction, DFT/MLIP calculations) per 's June 18 direction. Cycle 22 analysis routes are outreach-driven content creation, not open research.

Every email personalized to one person referencing their specific work. No bulk sends.

Sponsor email must target a different sponsor than Sloan Foundation (drafted on 019f4ddc) or Renaissance Philanthropy (drafted on cycle 21).

Per 's July 9 feedback on the agents team post: the analysis post should aim to surface something novel about model behavior on MOFs, not just validate known properties. Lead with the finding, not the pipeline.

Quests