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From https://www.sciencedirect.com/science/article/abs/pii/S0891584920316804
1d
Pulling together some resources of anecdotal/esoteric evidence for cures to autoimmune conditions like Vasculitis, Sjogrens Hashimoto, and rheumatoid arthritis.
Primarily focusing on rheumatoid arthritis (RA).
WIP; Roughly ordered by estimated effectiveness
https://x.com/luckynoelle/status/1855566501081981031?s=20
traditional doctor cure were steroids for life (remember, in their eyes, it’s incurable). Not a cure, but pharma money for life
This is what we're fighting against. We believe healing is possible.
This person cured Vasculitis, Sjogrens and Hashimoto, believe that they all start in your gut (including RA), and leaky gut is the trigger.
Leaky gut is the cause, only fix is diet
Tried Paleo AIP, found it hard, switched to Clean Keto with much better results - easier, less cravings.
https://x.com/DietDrsayajirao/status/1862024544300790024?s=20
Again, recommending Keto. Low carb, high protein.
Now, lets get into some more serious research.
Dietary Habits and Nutrition in Rheumatoid Arthritis
The authors suggest Mediterranean Diet adherence, limiting red meat, emphasizing fatty fish, olive oil, fruits/vegetables, and maintaining healthy body weight as adjunctive strategies alongside pharmacological treatment.
Gut dysbiosis plays a role in RA pathogenesis
Omega-3 fatty acids (from fatty fish) show ~35% reduction in RA risk due to anti-inflammatory properties
Green tea's EGCG compound can suppress inflammation in synovial tissue
Vitamin D deficiency correlates with disease activity, though supplementation results are mixed
In a study conducted on 40 RA female patients, daily supplementation with antioxidant (50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 mg vitamin C, and 40 mg vitamin E) ameliorated oxidative stress and disease activity but not the number of tender and swollen joints [172].
Not enough vitamin E!? See next section.
Bad foods? Possibly:
High sodium/salt, common in Western diets, induces SGK-1 expression, which increases Th17 lymphocyte differentiation and enhances autoimmunity
4+ cups/day associated with increased seropositive RA risk and RF positivity in some studies
Diterpene cafestol in unfiltered coffee and solvents used in decaffeination may be the culprits rather than caffeine itself
When smoking was controlled for, the association weakened
Regular consumption of sugar-sweetened soda increases RA risk
Red Meat, associated with increased inflammatory polyarthritis risk, harmful due to meat fats, nitrites, and excessive oral iron load (iron deposits can damage synovial tissue)
Though notably, a Chinese case-control study found no significant difference in red meat consumption between RA patients and controls
Mediterranean diet and rheumatoid arthritis: A nine-year cohort study and systematic review with meta-analysis
The authors note this suggests the overall dietary pattern matters more than individual foods working in isolation.
Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression and Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities
Conversation with Claude for my exploration on these papers.
Pre-clinical RA as a window:
Pre-clinical RA is a prolonged state before clinical arthritis and RA develop, in which autoantibodies can be present due to the breakdown of immunologic self-tolerance. As early treatment initiation before the onset of polyarthritis may achieve sustained remission, optimize clinical outcomes, and even prevent RA progression, the pre-clinical RA stage is showing the prospect to be the window of opportunity for RA treatment.
From Lin et al. (J Autoimmunity), paper 3:
Probiotics
The paper identifies specific strains with demonstrated prophylactic effects
Many of them are bacteria you'd normally find in the gut
See paper for specific strains
Fish oil (omega-3s) — "dietary intervention of tuna oil restored gut microbiome dysbiosis"
High-fiber diet — "restored immune dysbiosis including increased numbers of Tregs and an increased Th1/Th17 ratio in RA patients" plus decreased zonulin (improved gut barrier)
Inulin — "greatly inhibited production of pro-inflammatory cytokines SAA and TNF-α" and reduced fibrinogen (an RA autoantigen)
Vitamin D — "vitamin D supplementation may inhibit early RA progression by activating autophagy signaling pathways, rebalancing gut microbiota composition, and improving intestinal barrier function"
Vitamin D upregulates Atg16L1 (autophagy gene) → proper Paneth cell function → maintains gut-microbiota interface
Reduce sodium intake, high salt promotes dysbiosis and Th17 activation
The Lin et al. paper's core argument is that pre-clinical RA is the optimal intervention window.
400 mg of Vitamin E daily reduces pain by repairing the intestinal barrier.
From https://www.sciencedirect.com/science/article/abs/pii/S0891584920316804
Claude came up with a little diagram on how the mechanism of Vitamin E (gamma-Tocopherol) works to help.
Made by Claude, proceed with caution. https://claude.ai/share/3397d0ab-7ded-4ff6-98ca-90ac7c33c485
Most vitamin E supplements contain only α-tocopherol. This study suggests γ-tocopherol or mixed tocopherols may be more beneficial for gut-related conditions.
Techniques like humming, deep breathing, or ensuring cholinergic support (nutrients for nerve function) improved RA in over half of patients in one study cited anecdotally, by dampening inflammation via the spleen.
From https://www.nature.com/articles/s41591-025-04114-7
The study used implants for stimulation, but humming could be an easy, non-invasive alternative: https://feinstein.northwell.edu/news/insights/vagus-nerve-stimulation
Meditation is another option, which I would absolutely recommend!
Still researching, but it's come up a couple times now so it might be worth looking into.
Berberine is a bioactive compound (an alkaloid) found in plants like barberry and goldenseal, used in traditional medicine and sold as a dietary supplement.
Berberine provides nutritional support for maintaining healthy cholesterol and blood sugar levels, promoting GI microbial balance, and supporting healthy metabolism.
Berberine (from the gut microbiota paper) also activates Nrf2/HO-1
More on Nrf2 https://pmc.ncbi.nlm.nih.gov/articles/PMC11566362/
Talks about natural phenolic compounds for the treatment of RA
Nothing required but your own belief. At the end of the day, it is your own body that does the healing. Medicines, supplements, and remedies are just giving your body the tools to do so. Don't underestimate the power of your mind (and what your mind believes). This is the placebo effect, but many underestimate just how powerful it can be. Learn more about the placebo first, then understand why it is important to believe you can be healed.
Small sample size.
A more recent study shows that fasting is good, but it's mostly the same as an anti-inflammatory diet.
Conclusions: Compared with a guideline-based anti-inflammatory diet, fasting followed by a plant-based diet showed no benefit in terms of function and disability after 12 weeks. Both dietary approaches had a positive effect on RA disease activity and cardiovascular risk factors in patients with RA.
Jorge Flechas, MD lecture
(28:54) Borax mixed in water has been used to take care of arthritis. Now we have studies to understand how this works. https://ods.od.nih.gov/factsheets/Boron-HealthProfessional/
Mostly seems to be for osteoarthritis, not RA.
Lots of anecdotes for a bunch of different conditions.
Have any of you reading this considered the possibility that Lyme Disease could be the origin of your Parkinson's? I have read and researched Lyme so much that I seem to find it under every rock and every autoimmune / neuro problem. Treatment with a 21-day course of ivermectin (12mg) has benefitted many.
No need for Methotrexate.